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Nicole Eck has a diverse range of work experience. Nicole held various roles at The ALS Association, including Senior Vice President Operations, Vice President, Operations, Senior Director, and Vice President, Office of the CEO, starting in 2012 and currently ongoing. Prior to their time at The ALS Association, they worked at The Alzheimer's Association as Director, Chapter Relations from 2009 to 2012 and as Associate Director, Shared Fundraising Initiative from 2005 to 2009. Before that, they were a Director at Lee Perfect Transcription Co. from 2002 to 2004, and a Specialist at CNA Insurance from 1998 to 2002.

Nicole Eck holds a BGS degree in Counseling Psychology from North Park University. Nicole also attended Augustana College from 1992 to 1995, although their degree and field of study are not specified.