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Simon Shaw has spent their career in finance, starting out as a corporate financier at Hambros Bank Limited. Simon then moved on to Profile Therapeutics plc as their COO, followed by Gyrus Group Plc as their CFO. In April 2008, they took on the role of Non-Executive Chairman at Synairgen plc, a position they still hold today.

Simon Shaw attended the University College London, where they studied Latin and Greek.