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Caroline Henderson has extensive work experience, starting from 1991. Their most recent position is as a Senior Proposal Manager at Softek Enterprises, which they began in August 2022. Prior to that, they worked as a Proposal Manager and Technical Writer at an unspecified company since October 2018. In 2018, they also held the role of Senior Communications Analyst at TEKsystems from June to September. From March 2017 to May 2018, they worked as a Senior Communications Analyst at CSRA Inc under a contract with the Centers for Disease Control and Prevention.

Before their roles in communications, Caroline worked as a Research Scientist at Battelle (CDC) from January 2011 to March 2017. Caroline also served as a Microbiologist at the Atlanta Research and Education Foundation as a Guest Researcher for the CDC from June 2007 to December 2010. From May 2002 to May 2007, they were a Research Lab Manager at Emory University. Additionally, Caroline worked as a Lab Technician and Team Lead/Biochemist at Clemson University from 1999 to 2002.

Caroline's earliest work experience was in the field of radio and broadcasting. Caroline served as an On Air Personality and Music Director at various radio stations from March 1992 to August 1996. Prior to that, they were a District Staff Reporter at The Gainesville Times Newspaper from September 1991 to September 1992.

Caroline Henderson completed their Bachelor of Science (BS) degree in Microbiology, General from Clemson University, which they pursued from 1998 to 2001. Following their undergraduate studies, they continued their education at Clemson University and earned their Doctor of Philosophy (Ph.D.) in Biochemistry. The timeframe for their Ph.D. program is not specified.