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Barret Malkin's work experience begins in 2001, when they became the Franchise Owner/Proprietor of The UPS Store. From 2005 to 2012, they worked at Sanofi, starting as a Sales Representative and eventually becoming an Executive Aesthetic Sales Professional. In 2012, they joined PreCision Dermatology, Inc. as a Manager and stayed until 2014. From 2014 to 2015, they were the National Director at HM Compounding. Finally, in 2015, they became the Chief Commercial Officer and Founder of SKNV, a company focused on customized medicines and skincare solutions for dermatology practices.

Barret Malkin attended the University of Delaware from 1996 to 2000, where they obtained a Bachelor of Arts degree in Criminal Justice and pursued a minor in History.