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Since 1998, Pietrangelo has practiced law at Pietrangelo Cook, PLC, based in Memphis, Tenn. With licenses in New York, Tennessee, and the District of Columbia, he was an attorney with the Federal Trade Commission from 1967 to 1968, and later for Pfizer, Inc., from 1968 to 1972. Pietrangelo joined Schering-Plough Corporation in Memphis in 1972, first as legal director and then as associate general counsel. During that time, he was appointed visiting professor of law by the University of Tennessee and the University of Mississippi School of Pharmacy. In 1980, Pietrangelo left corporate law and focused on consumer products management, serving in a variety of executive positions at Schering-Plough Corporation prior to being named president of the Personal Care Products Group in 1985. In 1989, he was asked to join Western Publishing Group as president and chief operating officer. From 1990 to 1994, Pietrangelo was the president and chief executive officer of CLEO, Inc., a Memphis-based subsidiary of Gibson Greetings, Inc. that manufactured specialized paper products. From 1994 until 1998, he served as president of Johnson Products Company, a subsidiary of IVAX Corporation. Pietrangelo has served on the board of Medicis Pharmaceutical Corporationand currently serves on the boards of directors of the nonprofit American Parkinson Disease Association, SurgiVision, Inc., and Universal Insurance Holdings, Inc. Pietrangelo is currently managing partner of The Theraplex Company LLC.