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Orfeo Mazzella currently serves as a Senatore at Senato della Repubblica since October 2022. In addition to this role, Orfeo has been a libero professionista specializing in Odontoiatria since April 1992. Previously, Orfeo participated in a Perfezionato program at the University of Rome "La Sapienza" in May 1994. Orfeo Mazzella earned a degree in Odontoiatria e Protesi Dentaria from Università degli Studi di Napoli Federico II, completing studies between 1985 and 1992.