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Santhanam received his B. Tech in Civil Engineering (1978) from the Indian Institute of Technology, Madras and a Post Graduate Diploma in Management (1980) from the Indian Institute of Management, Ahmedabad.

Santhanam began his career as a management intern in May 1980 at Grindwell Norton, a Saint-Gobain Group company, then held various positions in the IT, Operations, Product Development, Sales and Marketing departments. In 1996, Santhanam worked closely with the Saint-Gobain Group to develop a strategic investment plan in India. In April 1997,

Santhanam was appointed General Manager of Saint-Gobain's Glass activities in India. On January 1, 2020, he was appointed Managing Director India. As of July 1, 2021 , he was appointed Managing Director, Asia-Pacific Region.