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Rocco Crescenzo has held a variety of roles in the medical field since 1999. Rocco has been a Clinical Associate Professor at PCOM since 1999, and an Assistant Professor and Acting Chief Medical Oncology at Temple University since 2007. From 2008 to 2015, they were the Director of Clinical Development at GSK, and from 2015 to 2019 they were the Global Clinical Lead at Novartis and the Global Project Development Lead and Clinical Regulatory Lead for Bosutinib at Pfizer. Since 2019, they have been the Chief Executive Officer at Hunter Oncology and the Chief Medical Officer at SAGA Diagnostics AB.

Rocco Crescenzo began their education in 1983 at La Salle University, where they earned a Bachelor of Arts in Biology, General in 1987. Rocco then attended Philadelphia College of Osteopathic Medicine and earned a Doctor of Osteopathy degree in 1992. Following this, they completed a residency in Internal Medicine at Graduate Health System - City Ave from 1992 to 1996. Finally, they were a Fellow in Hematology & Oncology at Thomas Jefferson University Hospitals from 1996 to 1999.