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Paul A. Insel received an M.D. from the University of Michigan and post-M.D. training at Boston City Hospital/Harvard Medical Service, the U.S. National Institutes of Health (NIH) and the University of California. San Francisco (UCSF). He served on the faculty at UCSF and subsequently joined UC San Diego (UCSD), where he is currently Distinguished Professor of Pharmacology and Medicine and Co-Director of the MD/PhD Training Program. Dr. Insel’s research efforts have focused on G-protein-coupled receptors (GPCRs), including studies of G-proteins and their effectors, signaling compartmentation in caveolae, GPCR expression and identification of novel GPCR therapeutic targets in a variety of disease settings. Dr, Insel is the author of over 470 scientific articles, including original studies, reviews and book chapters. Dr. Insel has been Editor-in-Chief of numerous scientific journals (including Journal of Clinical Investigation, American Journal of Physiology-Cell Physiology, and Molecular Pharmacology). He is currently Associate Editor of Pharmacological Reviews and Physiological Reviews and Editor-in-Chief of Annual Review of Pharmacology and Toxicology; U.S. Senior Editor, British Journal of Pharmacology and co-Head of Faculty, Faculty of 1000Prime in Pharmacology and Drug Discovery. Dr. Insel holds a Doc. Hon Causa from the University of Paris, is an elected member of the American Society for Clinical Investigation and the Association of American Physicians, a Fellow, American Association for the Advancement of Science and has received major awards from the American Association of MD/PhD Training Programs, American Physiological Society, Dutch Pharmacology Society, and American Society for Pharmacology and Experimental Therapeutics.