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Dominic Clarke started their work experience in 2013 as a Sales Advisor and Christmas Helper at Next Retail Ltd. In 2016, they moved on to more data-focused roles, working at Framed Data, Wrightington, Wigan and Leigh NHS Foundation Trust, and Peak. At Framed Data, they focused on feature engineering and selection, while at Wrightington, Wigan and Leigh NHS Foundation Trust, they worked on predictive modeling in healthcare business intelligence. At Peak, they took on roles as a Data Scientist before becoming the Data Science Team Lead in February 2022.

Dominic Clarke obtained a Bachelor's Degree in Mathematics BSc from Lancaster University in 2015 and went on to earn a Master's Degree in Data Science MSc from the same university in 2016.