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Machteld Van Opstal has a diverse work experience spanning several industries and roles. machteld is currently the Human Resources Director at OLV Ziekenhuis Aalst-Asse-Ninove since September 2021. Prior to that, they worked as an HR Manager at Beiersdorf from an unknown start date to September 2021. Machteld also held the position of HR Manager at MS Amlin (continental Europe) from an unknown start date to 2016. Before that, they worked as an HR professional (manager level) at Euroclear from an unknown start date to 2012. machteld'searlier experience includes working as an Employment Lawyer at Brussels Bar where they advised large international companies on various aspects of employment law. machteld also worked at Universiteit Gent-Vakgroep Sociaal Recht as an Assistant, teaching law students and managing international social security law projects in South Africa and China.

Machteld Van Opstal began their education in 1991, attending KULeuven and KUBrussel. machteld pursued a field of study in law and completed their studies in 1996. In the same year, they also enrolled at Université libre de Bruxelles, where they obtained a DES en droit social (Specialized Graduate Diploma in Social Law) in 1997. Additionally, Machteld Van Opstal attended Stellenbosch University, studying law, starting in 1996. In 2014, they furthered their education at Antwerp Management School, undertaking an Executive Masterclass in HRM, which they completed in 2015. It is not specified when they completed their studies at Stellenbosch University.