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Elsapeth McGuire has a diverse and impressive work experience in the healthcare field. Beginning in 2015, they worked as a Staff Registered Nurse at Highgate Private Hospital until 2020. In 2017, they joined the University College London Hospitals NHS Foundation Trust, where they served as a Neurosurgical nurse until early 2018. Following this, McGuire worked at The Royal Marsden NHS Foundation Trust as a Registered Nurse Oncology from 2018 to 2021. Elsapeth then transitioned to Effect Doctors, where they held the positions of Lead Nurse for the period of July 2021 to December 2021, and Clinical Operations Manager from December 2021 to the present. Most recently, McGuire has embarked on a new role as Clinical Lead at MySense.ai, starting in February 2023.

Elsapeth McGuire completed their Bachelor's degree in Adult Health Nursing from Sheffield Hallam University between 2014 and 2017. Elsapeth then pursued further education in the field of Oncology and Cancer Biology at both Royal Marsden School and University of East Anglia from 2018 to 2020, where they obtained a Post Graduate degree.