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Siegfried Gessulat began their work experience in 2011 as a Working Student at SAP, where they worked until 2014. In 2014, they returned to SAP as a Software Engineer and played a role in developing SAP Medical Research Insights, which became a standard product. Siegfried also worked on a co-innovation project with the American Society of Clinical Oncology. In 2016, they became a PhD candidate at SAP and continued in that role until 2019. In 2019, Gessulat joined MSAID as the Technical Lead for Machine Learning and became a Co-Founder of the company later that year.

Siegfried Gessulat completed a Bachelor of Science (B.Sc.) degree in International Business Administration and Information Technology from Ludwigshafen University of Business and Society from 2008 to 2011. In 2011, they also participated in a semester abroad program at Tongji University, focusing on Business Intelligence. Between 2011 and 2014, Gessulat pursued a Master's Degree in Computer Science at Freie Universität Berlin. Later, from 2016 to 2020, they attended the Technical University of Munich, where they obtained a Doctor of Philosophy (Ph.D.) degree in Biochemistry, Biophysics, Molecular Biology, and Computer Science.