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Niyati Sharma has a diverse work experience spanning multiple industries. Niyati started their career as a Dermatologist at Northwestern Dermatology in 2019, where they worked until October 2020. During this time, they also served as a Dermatologist at Monash Health from July 2019 onwards. In February 2020, they took on a role as an Adjunct Lecturer at Monash University and later joined Eastern Health as a Dermatologist in January 2020. Sharma then co-founded Inside Out Dermatology in April 2020 and also served as a Co-Founder and Dermatologist. Additionally, they worked as the Chief Medical Officer at MoleMap Australia from March 2021 to March 2023. In 2023, Sharma held the position of Consultant (digital healthcare) at MoleMap Australia & New Zealand and Consultant (digital health) at Mosh. Prior to their medical career, they were the Director of SereniTEA since September 2009.

Niyati Sharma completed their Masters of Public Health degree in Human Nutrition and Epidemiology from Johns Hopkins Bloomberg School of Public Health in 2019. Prior to that, they pursued a Paediatric Dermatology Fellowship at Northwestern University from 2017 to 2018. Although the start and end years are not provided, it is known that they obtained a degree of FACD from the Australian College of Dermatologists. Furthermore, Niyati Sharma studied Medicine at the University of Adelaide, but the specific start and end years are unknown. Niyati also attended MacRobertson Girls High School, although no degree or field of study is specified for this institution.