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Benoit Smagghe began their work experience in 2000 as a Research Assistant at Université des Sciences et Technologies de Lille (Lille I), where they optimized hybridization in situ techniques and analyzed the localization of non-symbiotic hemoglobins in leafs of the Cichorium hybrid. From 2002 to 2007, they worked as a Research Assistant at Iowa State University, focusing on the biophysical and biochemical characterization of Hexacoordinate Hemoglobins. During this time, they conducted experiments using stopped-flow and flash photolysis methods, analyzed in vitro and in vivo reactions of nitric oxide with different hemoglobin states, and solved the quaternary structure of a plant non-symbiotic hemoglobin. In 2007, they joined Immune Disease Institute as a Postdoctoral Fellow, where they studied the mechanisms and dynamics of integrin activation, including the function of the b-knee loop in the I-EGF2 domain and the characterization of conformational states. Finally, since 2011, they have been working as a Research Scientist at Minerva Biotechnologies, where they focus on the development of anti-cancer therapeutics that block the dimerization of the membrane receptor MUC1, as well as the development of cell-based assays for studying the effects of these therapeutics on cancer growth rate.

Benoit Smagghe's education history begins in 1999 when they attended the University of Lille 1 Sciences and Technology, earning a Bachelor's degree in Cell Biology and Physiology in the year 2000. benoit then went on to pursue a Master's degree in Enzyme Engineering, Bioconversion, and Microbiology at the Université de Technologie de Compiègne (UTC) from 2000 to 2001. Continuing their academic journey, Smagghe then enrolled at Iowa State University from 2002 to 2007, where they obtained a PhD in Biochemistry, Biophysics, and Molecular Biology.