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Kenneth Poss, Ph.D. is the James B. Duke Professor of Cell Biology, Professor of Biology, Professor in Medicine, and Director of the Duke Regeneration Center at the Duke University School of Medicine.

How and why tissue regeneration does (or does not) occur are critical questions. The biology of regeneration remains both challenging and fascinating, and new discoveries have the potential to impact clinical outcomes of many diseases of organ damage, including heart failure, Alzheimer’s disease, and diabetes.

It has been known for centuries that salamanders and fish regenerate complex tissues much more effectively than mammals. Zebrafish have emerged as a central model system for studying regeneration, due to their ability to regenerate myriad tissues and to the availability of molecular genetic tools. Over the past decade, the laboratory has spearheaded the use of zebrafish to reveal concepts and mechanisms of regeneration.