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Isgett joined McLeod Health in 1997 and currently as Chief Operating Officer is responsible for the oversight of administrators at the seven McLeod hospitals. She holds a Master of Science in Nursing from the Medical University of South Carolina and MBA from Duke University. She spent the majority of her clinical career as an emergency flight nurse. Since joining McLeod, she has served as Senior Vice President of Corporate Quality, helping McLeod gain a national reputation for quality of care, and has also had oversight of McLeod Physician Associates, a network of 90 physician practices stretching from the midlands to the coast.

Since 2013, Isgett served as a member of the South Carolina Hospital Association Board of Trustees and in 2020 was named board chair. She is also on the Coker University (Hartsville, SC) Board of Trustees. She served as co-chair of the 2005 Institute Healthcare Improvement Forum. Isgett has been the recipient of the Milliken Medal of Quality from the South Carolina Quality National Forum and the Lewis Blackman Patient Safety Award from the South Carolina Hospital Association. She was a 2011 Liberty Fellow at the Aspen Global Institute.