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Nissen Isakov has had a successful career in various leadership roles. Nissen is the retired CEO of LCR Embedded Systems, where they served from 2013 until their retirement in December 2021. Prior to that, they were the CEO and Chief Executive Officer of LCR Embedded Systems from December 2013 to January 2022. Nissen also founded and served as CEO of LCR Electronics, Inc from 1985 to 2013. Before that, they co-founded and worked as Managing Director of Supprescraft PTY Ltd from September 1973 to November 1984.

Nissen Isakov attended Clapham High School in Pretoria from 1961 to 1966. Nissen then pursued an Engineer's Degree in Electrical and Electronics Engineering from the University of Pretoria/Universiteit van Pretoria, which they completed from 1968 to 1973.