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Professor Karnieli is the former Director of the Institute for Endocrinology, Diabetes and Metabolism at the Rambam Medical Center in Haifa.

Professor Karnieli's main research interests are the molecular mechanisms for regulating cellular glucose uptake and transporters and their implications in diabetes, obesity and insulin resistance; Gene therapy modalities to trans-differentiate human cells toward beta-cells as a potential cure for type 1 diabetes; Medical informatics, telemedicine and personalized medicine. He has published about 70 peer reviewed papers and reviews. Professor Karnieli serves on the editorial board of several scientific journals and review boards.

Professor Karnieli is a retired Colonel from the Israel Defense Forces Medical Corps and is a former Deputy Director of the Rambam Medical Center.