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Akwasi is a senior fellow at the US-based Humanity United and he sits on the boards of Human Rights Watch and the Fund for Global Human Rights. He held several leadership positions at the Ford Foundation in New York and in West Africa, and he was the executive director of African grant-making foundation TrustAfrica. He is the former chair of the board of the Fund for Global Human Rights, the Resource Alliance, and the Open Society Initiative for West Africa. He served on the boards of the Society for International Development and Oxfam America, among others. In 2015, he received the Africa Philanthropy Award in Tanzania.

Akwasi holds a PhD in medical sociology from the University of Connecticut and a BA Honours in sociology from the University of Cape Coast in Ghana.