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Dr. François is specialist in Intensive Care medicine and Anaesthesiology at the University Hospital of Limoges, France. He works in a 22 bed medical/surgical ICU and is the head of the Limoges Clinical Investigation Center (Inserm CIC-P 1435) of which main expertise is Infectious Diseases in critically ill patients. He has been national coordinator for numerous emergency trials especially in Sepsis, VAP and VAP prevention, and has participated in several advisory boards for Sepsis and VAP multinational trials, independent Clinical Evaluation Committees and Adjudication Committees. He is author of many publications in Infectious Disease in the ICU especially about Sepsis and VAP and is also reviewer for several medical journals in the ICU field. He has an expertise in the practical bedside organization of clinical research in the ICU. He has also an interest in more translational studies and research about the immunological disorders of Sepsis evaluated by flow cytometry and its potential treatments. He created the CRICS network dedicated to clinical research in Sepsis trials in 2007 and is now co-leading the French TRIGGERSEP research network (F-CRIN certification within ECRIN) which integrate all research activities in Sepsis from basic science to clinical trials. Since 2012, he is coordinating the COMBACTE consortium within the IMI framework.