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David H. Munn, M.D., is a pioneer in T cell activation and indoleamine 2,3-dioxygenase (IDO) research, serves as Professor of Pediatric Hematology-Oncology at the Medical College of Georgia, Augusta University, and is a member of the Georgia Cancer Center. Dr. Munn and colleagues were the first to identify the role of IDO in immunologic tolerance and its importance for tumor immunology. His laboratory focuses on basic research in tumor immunology and on translation to Phase 1/2 clinical trials for cancer immunotherapy in children and studies the regulation of T cell activation by tolerogenic dendritic cells and regulatory T cells (Tregs) in the setting of cancer, and the molecular links among IDO, Tregs, antigen-presenting cells, and immunoregulatory checkpoints (PD-1, CTLA-4, and PTEN).