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Uzma Jafri began their work experience as a Resident at Banner in 2007 and continued until 2010. Uzma then worked as a Nocturnist at Banner Del Webb Medical Center from 2012 to 2018 and at Banner Boswell Medical Center from 2014 to 2018. In 2011, they served as the Medical Director at The Inn at Freedom Plaza, and in 2016, they became the Medical Director at Hospice of the West. Uzma Jafri also worked as an Adjunct Faculty Member at BANNER - UNIVERSITY MEDICAL CENTER PHOENIX CAMPUS starting in 2012. Additionally, they were an Associate Producer for the Mommying While Muslim Podcast starting in 2018. Uzma is currently a Physician at Fawkes, MD since 2023.

Uzma Jafri holds a Doctor of Medicine (MD) degree from Ross University School of Medicine.