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Melinda Locklear began their work experience in 2003 as the Vice President for Carolina Donor Services. In the same year, they started working for HonorBridge, initially assuming the role of Chief Quality and Information Officer. Throughout their tenure at HonorBridge, they held various roles, including the position of Chief Support Officer from June 2023 until the present.

Melinda Locklear has a Bachelor of Science degree in Chemistry from Salem College. Melinda also holds a Master of Science degree in Organic Chemistry from Wake Forest University. The specific start and end years for each degree have not been provided.