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Deneen is a healthcare executive grounded in clinical medicine, scientific research, and care delivery. Deneen was the Executive Vice President for Research and Development for UnitedHealth Group (UHG), where she was responsible for building new businesses and creating innovative payment and delivery system frameworks. She was also the Founder and CEO of MYnetico, a digital weight management platform acquired by UHG in 2006. Earlier, she served as Chief Medical Officer of ARIA Health Care System and Health Partners of Philadelphia. Deneen began her career as a resident in Pediatrics and fellow in Hematology & Oncology at the Children’s Hospital of Philadelphia, where she founded the first pediatric hospitalist program.

In 2022, Deneen was named Modern Healthcare's Top Innovator, in 2014, she was an Emmy® Award winner and in 2013, a CES® Innovation Design & Engineering Innovation Honoree.