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Joyce O'Connor began their work experience in 1998 as the Director of Medical and Scientific Programs for the Huntington's Disease Society of America. Joyce held this role from June 1998 to November 2001. In November 2001, O'Connor joined Health Science Communications as the Vice President of Client Services, a position they still hold.

Joyce O'Connor completed their undergraduate education at Drew University from 1991 to 1995, where they obtained a Bachelor of Arts degree in Psychobiology and Biochemistry. Following this, they pursued further education at the Weill Cornell Graduate School of Medical Sciences from 1995 to 1998, earning a Master of Science degree in Neuroscience.