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Esme Lowe has a diverse range of work experience in the arts and non-profit sectors. Esme currently serves as the Head of Programmes and Events at Founders Pledge, a charity that mobilizes entrepreneurs to address global challenges. Esme previously held positions such as Head of Philanthropy at Serpentine Galleries, where they secured significant annual donations for the organization, and Development & Events Manager at Camden Arts Centre, where they designed and implemented fundraising strategies and managed events. Esme also worked at Tate as a Public Funding Officer and Development Assistant, as an intern at FACT and Sprout Pictures, and as a Creative Apprentice at The Everyman Playhouse Theatre earlier in their career. Esme's roles have involved fundraising, event management, relationship building, and strategic planning.

Esme Lowe studied at the Manchester School of Theatre from 2009 to 2012, where they earned a Bachelor of Arts degree in Acting.