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Xiaorui Guo began their work experience at the University of Illinois Urbana-Champaign in October 2014 as a Ph.D. Candidate and completed their role in December 2020. They later joined Empress Therapeutics in January 2021 as a Scientist and was promoted to Scientist II in March 2022.

Xiaorui Guo completed a Bachelor of Science (B.S.) degree in Chemical Biology from the University of California, Berkeley from 2010 to 2014. Following this, from 2014 to 2020, Xiaorui pursued a Doctor of Philosophy (PhD) degree in Natural Products Chemistry and Pharmacognosy at the University of Illinois Urbana-Champaign.