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Matt is Head of Human Genetics and Senior Group Leader at the Wellcome Trust Sanger Institute. Matt is the scientific director of the Deciphering Developmental Disorders program and was a major contributor to the UK 10K projects. He has pioneered the analysis of whole exomes in clinically relevant disorders that previously failed diagnostic methods and has led an initiative to characterize structural variation in the human genome. Matt has been awarded the Balfour Lecture by the Genetics Society and the Crick Lecture prize for accomplishments in genetics and is a Fellow of the Royal Society.