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Rhett is an Associate Professor at the University of Cincinnati, College of Medicine in the Department of Molecular Genetics, Biochemistry and Microbiology. He is a structural biologist with more than 19 years of experience in using X-ray crystallography to solve the high-resolution structures of macromolecules. The focus of his research program is to use structural and biophysical approaches to characterize transcription complexes that regulate signaling from the NOTCH pathway.