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Dr. Mann is the Lewin Chair and Professor of Medicine, Cell Biology and Physiology, Chief of the Division of Cardiology at the Washington University School of Medicine, and Cardiologist in Chief at Barnes Jewish Hospital in St. Louis. He received his medical degree from Temple University School of Medicine in Philadelphia and completed fellowships in clinical cardiology at the University of California San Diego, and Massachusetts General Hospital in Boston.

Dr. Mann's primary research interest has been the molecular and cellular basis of heart failure, with particular emphasis on the role of innate immunity in disease progression and recovery of the failing heart. The author of numerous peer reviewed articles on the role on inflammatory mediators in cardiac remodeling and myocardial recovery, Dr. Mann is also the editor of Heart Failure, A Companion to Braunwald’s Heart Disease, and a co-editor of Braunwald’s Heart Disease, the leading textbook in cardiovascular medicine.

Dr. Mann is the founding editor for JACC: Basic to Translational Science, and is currently the on the Editorial Board for a number of leading cardiovascular journals. He is a member of the American Society for Clinical Investigation, the Association of American Physicians the Association of University Cardiologists, the Heart Failure Society of America and the American Clinical and Climatological Association. He is the past president of the Heart Failure Society.