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Elizabeth Clayborne attended Duke University as an undergraduate where she designed her own major in Medical Ethics and Religion. Prior to medical school she completed a two-year research fellowship at National Institutes of Health in the Social and Behavioral Research Branch of the National Human Genome Research Institute with a research focus on race, ethnicity and genetics. Dr. Clayborne attended to medical school at Case Western Reserve University where she completed a dual MD/MA Bioethics degree in 4 years.

She went on to complete residency in Emergency Medicine at the George Washington University Hospital and served as Chief Resident in her fourth year. Dr. Clayborne is currently a faculty member at the University of Maryland School of Medicine Department of Emergency Medicine with an academic focus on ethics, health policy, end of life care, health disparities and innovation/entrepreneurship. She developed a novel epistaxis device bleedfreeze.com as a resident and in 2015 was awarded the NSF I-Corps grant which helped to launch her company Emergency Medical Innovation, LLC. She is the former Chair of the MedChi Committee on Ethics and Judicial Affairs, serves on the Ethics Committee of the American College of Emergency Physicians and is an active member of the Society of Academic Emergency Medicine, the American Medical Association and the National Medical Association.