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Dr Hirst is Chair of Factor Therapeutics Limited (previously Tissue Therapies Limited), The John Villiers Trust and the Advisory Board of the Institute for Molecular Bioscience at the University of Queensland. She is also Director of the Gold Coast Health and Hospital Service.

Dr Hirst has formerly held Board membership of a number of organisations including Medibank Limited, Suncorp Metway Limited, Peplin Limited, Avant Insurance Limited and ImpediMed Limited.