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Amelia Guo began their work experience in 2017 as an undergraduate research student at The Hospital for Sick Children. Amelia later became a clinical research assistant before transitioning to McMaster University, where they held roles as a teaching assistant, a graduate researcher, and a research assistant. In 2021, Amelia joined Dose Biosystems as a research associate. Amelia then moved to BenchSci in 2022, where they have taken on positions as a scientific analyst, scientist II, scientist III, and Science Lead & Product Owner.

Amelia Guo's education history includes an Honours Bachelor of Health Sciences degree in Biomedical Discovery & Commercialization from McMaster University. Amelia also holds a Master of Science degree in Biochemistry from McMaster University.