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Dr. Embers’ research program regarding Borrelia burgdorferi and Lyme disease is designed around two major foci: (1) novel treatments for Lyme disease; and (2) immunodiagnosis for B. burgdorferi infection and cure. The first research goal is to develop and evaluate novel treatments or antibiotic regimens for eradication of acute and persistent B. burgdorferi infection. The second goal is to develop a quantitative multi-antigen test that expands detection limits and helps to distinguish persistent infection from clinical cure. By studying the natural course of infection in animal models, her group hopes to facilitate a better understanding of the clinical quandaries of human Lyme disease, including effective diagnosis and treatment.