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Carlo Mastrangelo has a wealth of work experience, beginning in 1995 with the Baltimore Blast, where they served as Head Athletic Trainer. In 1999, they moved to The Bullis School, where they were Head Athletic Trainer and Health Education Instructor. In 2005, they joined Orthocare Solutions, Inc. as a Sales Rep/Orthotic Fitter. In 2007, they began working for DePuy Synthes Companies as a Trauma/OrthoBiologics sales rep. In 2008, they joined SeaSpine as a Territory Sales Manager - Mid-Atlantic. In 2018, they moved to Onkos Surgical as an RSM, Oncology - Mid Atlantic. In 2019, they began working for BONESUPPORT AB as an RSM - Northeast. Most recently, in 2022, they joined Avitus Orthopaedics as a Regional Sales Manager.

Carlo Mastrangelo received their Bachelor of Science in Sports Medicine from Salisbury University in 1993. Carlo then went on to obtain their Master of Science in Health Education/Wellness Promotion from the University of Kentucky in 1995.