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Sam is the COO of the Francis Crick Institute - a world-leading biomedical research organisation which she joined from a career in the NHS as a noted healthcare leader. Sam was CEO of the Taunton and Somerset NHS Foundation Trust and before that, established and led the South Devon and Torbay CCG. Earlier in her career, as a practising GP, she led the formation of a practice based commissioning consortium.

Sam offers strong ESG credentials, as a past National Advisory Council Member of the King's Fund and an active Mentor for the NHS Innovator Accelerator Programme. She is a Non-Executive Director of the York Health Economics Consortium.