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Long Phi Le has extensive experience in the field of pathology informatics. In 2010, they began working at the Massachusetts General Hospital as an Associate Chief of Pathology Informatics, an Assistant Professor of Pathology, and a Director of Computational Pathology. In 2013, they became Co-Founder of ArcherDx and Medical Director of the Clinical Research Sequencing Platform at the Broad Institute. In 2014, they took on the role of Director of Technology Development at the MGH Center for Integrated Diagnostics.

Long Phi Le began their education in 1995, earning a Bachelor's degree in both Chemical Engineering and Biology from the Massachusetts Institute of Technology. Long Phi then continued their education at the University of Alabama at Birmingham, earning a Doctor of Medicine (M.D.) and Doctor of Philosophy (Ph.D.) in Medicine and Molecular Cellular Pathology in 2006.