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Rifat Pamukcu, M.D., has served as a member of our board of directors since May 2022 and previously served on the board of directors of Atrin

Pharmaceuticals Inc. at the time of its acquisition by Aprea. Dr. Pamukcu has extensive experience in pharmaceuticals and drug development, with a

particular focus on oncology. He currently serves as the President and CEO of RxMP Therapeutics, Inc. He was also a co-founder, Director and CSO of Cell Pathways (NASDAQ:CLPA) until its acquisition by OSI Pharmaceuticals in 2003. Dr. Pamukcu has been a member of the Advisory Council to the National Prostate Cancer Coalition, the GI Oncology Task Force of the American Gastroenterological Association, Executive Steering Committee of the Gastroenterology Research Group and Scientific Advisory Board of the Hereditary Colon Cancer Association. He has authored or co-authored over 110 journal articles, book chapters and abstracts in the fields of gastroenterology, cancer, cancer chemoprevention and signal transduction systems and is an inventor on over 150 issued or pending patents in the areas of drug discovery and development of agents for cancer prevention and therapeutics, inflammatory bowel disease, osteoporosis and the prevention and treatment of hemorrhage. Dr. Pamukcu holds a B.A. in Biology from the John Hopkins University and an M.D. from the University of Wisconsin School of Medicine. He completed his Internal Medicine Residency at Rush Presbyterian St. Luke's Medical Center and his Fellowship in Gastroenterology and Hepatology at the University of Chicago.