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Melissa Gaines has over 25 years of work experience in the clinical research field. Melissa began their career in 1989 as a Counselor and Intensive Case Manager at Community Services Group. In 1995, they accepted a position as a Research Associate and Research Manager at the University of Maryland School of Medicine, Center for the Behavioral Treatment of Schizophrenia. In 1999, they moved to George Washington University as a Clinical Research Coordinator. In 2000, they became a Clinical Scientist at Pfizer, Neurosciences Division. In 2002, they joined INC Research as a Clinical Research Associate, and was promoted to Clinical Team Lead and then Senior Clinical Team Lead. In 2010, they moved to ReSearch Pharmaceutical Services as a Clinical Research Manager. In 2011, they returned to INC Research as a Director of Clinical Operations. In 2015, they joined Worldwide Clinical Trials as a Senior Director of Clinical Operations Site Management. Finally, in 2022, they accepted a role as Vice President of Clinical Operations at Annovis Bio, Inc.

Melissa Gaines attended Millersville University of Pennsylvania from 1986 to 1990, where they earned a Bachelor of Arts degree in Psychology.