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Manuel Bonilla has a strong background in legislative and advocacy work. Manuel began their career as a Legislative Aide in the U.S. Senate, where they provided support on domestic issues such as health care and Social Security. Manuel then moved on to the American Academy of Ophthalmology, where they served as a Legislative Representative, representing ophthalmologists before the U.S. Congress on physician issues. Manuel joined the American Society of Anesthesiologists® in 1997 and held various roles, including Director for Congressional and Political Affairs and Chief Advocacy Officer. In these positions, they led teams of professionals and actively advocated for the organization's agenda before Congress, federal agencies, and state legislative and regulatory bodies.

Manuel Bonilla has a Bachelor of Arts degree in Politics from Washington and Lee University. Additionally, they hold a Master of Science degree in Health Care Management from Marymount University. The specific years of their education are unknown.