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C.J. Keffer's work experience began in 1999 at Accenture, where they worked as a Senior Consultant until 2003. In 2004, they joined AstraZeneca Pharmaceuticals as a Forecasting Manager for nine months before transitioning to UPMC Health Plan as a Senior Financial Analyst. From 2006 to 2020, C.J. Keffer worked at Mylan in various roles, including Director of Global Finance Technology and Senior Director of Global Financial Planning & Analysis. In 2020, they joined HM Health Solutions as the Vice President of Finance until 2021. C.J. Keffer's most recent role is the Vice President of IT, Financial Planning & Consolidation at Advantage Solutions, starting in 2023.

C.J. Keffer earned a Bachelor of Science degree in Business / Computer Systems Management from Grove City College between 1995 and 1999. Later, between 2007 and 2011, Keffer pursued a Master of Business Administration - MBA in Applied Business at Waynesburg University.