CA, United States
Attention recruitment agencies:ÌýAll agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.
4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases. Ìý
We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.
To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.
In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.
Company Differentiators:Ìý
• Ìý ÌýFully integrated clinical-phase company with internal manufacturing
• Ìý ÌýDemonstrated ability to move rapidly from idea to IND
• Ìý ÌýFive candidate products in the clinic and two declared pre-clinical programs
• Ìý ÌýRobust technology and IP foundation, including our TVE and manufacturing platforms
• Ìý ÌýInitial product safety and efficacy data substantiates the value of our platforms
• Ìý ÌýOpportunities to expand to other indications and modalities within genetic medicine
The Director of SEC Reporting and SOX will leadÌýthe SEC reporting and the SOX program. This is a highly visible role that offers the opportunity to work with various Finance functions within the Company, includingÌýAccounting,ÌýFP&A, Investor Relations, Treasury, Stock Administration, and Corporate Tax, as well as HR, Legal, and various operational functions, which will allow you to gainÌýa strong understanding of the Company’s business and operations.Ìý
The ideal candidate has strong knowledge of US GAAP and SOX 404 compliance requirements and biotech industry experience.
RESPONSIBILITIES: Ìý
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Base salary compensation range $210,000 - $238,000
Please note: the base salary compensation range and actual salary offered to the final candidate depends on various factors: relevant work experience, skills, and years of experience
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